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KMID : 0043319940170030145
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.145 ~ p.149
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Hypotensive and Spasmolytic Activities of Crude Extract of Cyperus scariosus
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Gilani Anwar H.
Janbaz K.H.
Zaman M.
Lateef A.
Tariq S.R.
Ahmad H.R.
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Abstract
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Intravenous administration of hydro-methanolic extract of Cyperus scariosus (3-10 mg/kg) produced hypotensive and bradcardiac effects. These effects remianed unaltered in atropinized animals indicating that cardiovascular effects of the plant extract are not medliated through activation of muscarinic receptors. In the in vitro studies, it suppressed the spontaneous contractions of guinea-pig paired atria, rat ulterus and rabbit jejunum in a concentration-dependent (0.1-1 mg/ml) manner. It also inhibited histanmine or acetylcholine-induced contractions of guinea-pig ieum indicating non-sepcific spasmolytic action. In rabbit aorta, it inhibited norepinephrine as well as (80mM)-induced contractions at similar concentrations (0.1-1 mg/ml). These data indicate that cyperus scariosus contains channel blocker-like constituent(s) which may explain hypotensive effect observed in vivo and the general spasmolytic activity of plant explain its folkloric use in diarrhoea.
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KEYWORD
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Cyperus scarious, Hypotensive, Spasmolytic, In vivo, In vitro
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